Probably first of several such queries for a trip from upstate NY to Upstate NY (yeah-never just out and back eh?) Anyway highpoints are memphis, Clarksdale Ms, New Orleans, Texas (some gulf and Austin Ozarks and Russell Ak,...from there not sure, Time may become a factor) ANYWAY, easiest for me to look at maps and where in doubt about routes, ask here! So...Route 220 to us route 50 to memphis...is 220 horribly longer than route 81 south...I am SOOO tired of that road! I think we took 11 once...kinda nice but it looks like 220 gets us wester and I've never been on it AFAIK.