I'll be coming from Virginia across I-64.
When I get to St. Louis -- assuming I survive the passage through East St. Louis (I'll save the interesting tale of driving through ESL on a Sunday morning with my LT's final drive making LOUD, bumpy noises!) -- I have the choice of picking up I-70 and going over the north side of St. Louis, or staying on I-64 and going pretty much straight through the city until 64 turns into Rt. 40 and then meets I-70 near Wentzville.
Looking for advice as to whether to immediately pick up I-70 or go straight on I-64.