Sort of regret being a party pooper, but have to add to some of the concerned comments here. I picked up my 11S from a fellow in Louisville, KY the last week of April, three years ago. I intended to visit family in central Iowa, then take a nice meandering ride back to the Seattle area. I expected it would take 1 day to get to my brother's home, it took 2 1/2 days, battered by heavy rain and wind (literally blown off the highway in Illinois) the riding was very difficult.
After a day or so of rest, I departed on my "detour" route via Texas/Arizona etc to get home. The Rockies were covered by blizzards from Canada through Colorado. The two days it took just to get to New Mexico were done with very high cross winds, probably 35mph gusting to 50+. My brother-in-law (also from Iowa) is a long haul trucker, during this same period he spent 3 days parked with his big rig in Wyoming enroute to SF, even the major freeways were heavily impacted.
That being said, I do hope you're watching the weather reports VERY closely. There are some darn nice sights to see on US50. We lived near 50 in Nevada for many, many years. If you yearn for some wide open vistas, you'll definitely find them there.